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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? August and September are the most popular months to cruise between Spain and Italy and there are 212 departures available from sixteen of the world's leading cruise lines.
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111 Cruises (212 Cruise Departures)
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 03 November 2024
Countries Visited: Spain, Morocco, Portugal, France (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$2,420
SUITE
$3,569
From 2,420
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$3,528
OCEANVIEW
$4,256
BALCONY
$4,256
SUITE
-
From 3,528
View Trip
8 Day Florence, Rome, Palma & More with Virgin Voyages
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 29 June 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$2,578
OCEANVIEW
$3,002
BALCONY
$3,297
SUITE
$6,668
From 2,578
View Trip
11 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 16 May 2025
Countries Visited: Spain, Corsica, Sardinia, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
$3,054
OCEANVIEW
$4,147
BALCONY
$5,245
SUITE
$11,886
Save 1,254
From 2,764
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 June 2024
Countries Visited: Spain, Sardinia, Italy
Early Booking With Easy Drink Package
INSIDE
-
OCEANVIEW
-
BALCONY
$994
SUITE
-
From 994
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 15 April 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,432
SUITE
-
From 24,432
View Trip
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Unique EscapesExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,153
SUITE
$8,286
From 7,153
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: Spain, France, Italy, Sardinia
Essential FareDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$8,959
BALCONY
$11,236
SUITE
-
From 8,959
View Trip
8 Day Mediterranean with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 01 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,724
OCEANVIEW
$1,803
BALCONY
$2,338
SUITE
$2,872
From 1,724
View Trip
15 Day France, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 June 2025
Countries Visited: Spain, France, Sardinia, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Exclusive Deal
INSIDE
$2,528
OCEANVIEW
$2,776
BALCONY
$3,469
SUITE
$7,825
From 2,528
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+4 more), Sicily, Greece, Montenegro, Croatia
Exclusive Deal
INSIDE
$3,026
OCEANVIEW
$3,323
BALCONY
$3,768
SUITE
$10,203
From 3,026
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$1,486
OCEANVIEW
$1,992
BALCONY
$2,475
SUITE
$3,198
Save 638
From 1,340
View Trip
8 Day France And Italy with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Sep 2024
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
Exclusive Deal
INSIDE
$2,130
OCEANVIEW
$2,427
BALCONY
$2,674
SUITE
$5,149
From 2,130
View Trip
11 Day Europe with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Dawn
Departure: 07 October 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,046
OCEANVIEW
$3,275
BALCONY
$4,193
SUITE
$4,729
From 3,046
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Alicante to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 07 November 2024
Countries Visited: Spain, Sardinia, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$698
SUITE
-
From 698
View Trip
13 Day Barcelona to Cannes, Rome & Tuscany with Virgin Voyages
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 25 September 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
INSIDE
$4,539
OCEANVIEW
$4,686
BALCONY
$5,153
SUITE
$10,584
From 4,539
View Trip
18 Day Canary Islands And Madeira with MSC Cruises
Cruise

18 Days (17 Nights) Las Palmas de Gran Canaria to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 17 March 2025
Countries Visited: Spain, Portugal, Morocco, Sicily (+3 more), Greece, Italy, Croatia
Save And Sail Offer
INSIDE
$3,191
OCEANVIEW
$4,032
BALCONY
$6,280
SUITE
-
From 3,191
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+2 more), Sardinia, Sicily
Exclusive Deal
INSIDE
$2,776
OCEANVIEW
$2,974
BALCONY
$3,469
SUITE
$8,221
From 2,776
View Trip
11 Day Flavors Of The Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 18 September 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$10,802
BALCONY
-
SUITE
$16,563
Save 5,248
From 10,802
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 August 2024
Countries Visited: Spain, Italy, France
Exclusive Offer
INSIDE
$1,986
OCEANVIEW
$2,508
BALCONY
$2,514
SUITE
$7,161
Save 2,716
From 1,986
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
Exclusive Deal
INSIDE
$2,776
OCEANVIEW
$3,073
BALCONY
$3,617
SUITE
$8,518
From 2,776
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+4 more), Greece, Montenegro, Croatia, Malta
Exclusive Deal
INSIDE
$3,818
OCEANVIEW
$4,115
BALCONY
$4,808
SUITE
$12,876
From 3,818
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Greece, Turkey, Italy
Exclusive Offer
INSIDE
$2,531
OCEANVIEW
$3,094
BALCONY
$3,094
SUITE
$8,565
Save 3,631
From 2,531
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 29 April 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$855
BALCONY
$1,004
SUITE
$1,330
From 855
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Barcelona to Livorno
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaside
Departures: Oct 2024 to Apr 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$853
OCEANVIEW
-
BALCONY
$1,081
SUITE
$1,458
From 1,081
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 13 June 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$2,517
OCEANVIEW
$2,857
BALCONY
-
SUITE
-
Save 3,025
From 2,517
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy
Exclusive Deal
INSIDE
$1,288
OCEANVIEW
$1,486
BALCONY
$1,635
SUITE
$3,763
From 1,288
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Aug 2025
Countries Visited: Spain, France, Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,940
SUITE
$7,247
From 5,940
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Offer
INSIDE
$2,469
OCEANVIEW
$2,796
BALCONY
$3,195
SUITE
$9,486
Save 3,276
From 2,469
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jul 2024 to Sep 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,358
OCEANVIEW
$2,248
BALCONY
$3,368
SUITE
$5,112
Save 828
From 1,738
View Trip
Results: 31-60 of 111

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