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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 233 departures available from sixteen of the world's leading cruise lines.
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130 Cruises (233 Cruise Departures)
9 Day Rome to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 10 November 2025
Countries Visited: Italy, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$8,118
BALCONY
$9,306
SUITE
$9,009
From 8,118
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$8,761
OCEANVIEW
-
BALCONY
-
SUITE
$11,659
From 8,737
View Trip
17 Day An Extended Journey Around The Mediterranean with Explora Journeys
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Morocco, Portugal
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$13,068
SUITE
$15,147
From 13,068
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Saturn, Viking Vela, Viking Venus, Viking Vesta
Departures: May 2025 to Sep 2026
Countries Visited: Italy, Croatia, Sicily, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$11,677
SUITE
$18,805
Save 1,950
From 11,677
View Trip
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,111
SUITE
$19,268
Save 2,069
From 8,111
View Trip
9 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 June 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,039
OCEANVIEW
$2,729
BALCONY
$3,592
SUITE
$8,173
Save 2,876
From 2,039
View Trip
8 Day Spain And Adriatic with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 23 September 2024
Countries Visited: Italy, Croatia, Malta, Spain
Exclusive Deal
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,674
SUITE
$11,683
From 1,882
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
11 Day Majestic Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 July 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+3 more), Sicily, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,197
SUITE
$15,455
Save 6,183
From 14,197
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,981
OCEANVIEW
$3,575
BALCONY
$4,743
SUITE
$5,813
From 2,981
View Trip
Results: 121-130 of 130

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