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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 233 departures available from sixteen of the world's leading cruise lines.
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130 Cruises (233 Cruise Departures)
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,111
SUITE
$19,268
Save 2,069
From 8,111
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
22 Day Venice to Barcelona with Silversea
Cruise

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 26 July 2024
Countries Visited: Italy, Croatia, Montenegro, Albania (+5 more), Malta, Sicily, Sardinia, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,582
BALCONY
$24,552
SUITE
$36,333
From 21,582
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 14 June 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,083
OCEANVIEW
$5,358
BALCONY
$5,814
SUITE
$7,348
From 4,083
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 09 September 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$847
SUITE
-
From 847
View Trip
17 Day An Extended Journey Around The Mediterranean with Explora Journeys
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Morocco, Portugal
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$13,068
SUITE
$15,147
From 13,068
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 06 August 2024
Countries Visited: France, Italy, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,860
BALCONY
$10,345
SUITE
$20,394
From 8,860
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,748
SUITE
$42,860
From 22,748
View Trip
8 Day France, Italy & Greece Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 23 June 2025
Countries Visited: Italy, Croatia, Greece, France (+1 more), Spain
Exclusive Deal
INSIDE
$1,958
OCEANVIEW
$2,655
BALCONY
$3,138
SUITE
$4,852
Save 814
From 1,770
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Livorno to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 June 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$571
SUITE
-
From 571
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,686
OCEANVIEW
$5,527
BALCONY
$5,993
SUITE
$7,755
From 4,686
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain
Exclusive Deal
INSIDE
$2,776
OCEANVIEW
$3,073
BALCONY
$3,469
SUITE
$8,518
From 2,776
View Trip
10 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 24 August 2024
Countries Visited: Italy, Sicily, Malta, Corsica (+2 more), France, Spain
Exclusive Offer
INSIDE
$2,265
OCEANVIEW
$2,321
BALCONY
$2,990
SUITE
$7,933
Save 2,880
From 2,265
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,627
OCEANVIEW
$2,974
BALCONY
$3,271
SUITE
$8,221
From 2,627
View Trip
8 Day Italy, France, & Spain Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 10 August 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive Offer
INSIDE
$1,796
OCEANVIEW
$2,039
BALCONY
$2,545
SUITE
$5,497
Save 2,259
From 1,796
View Trip
12 Day Greece, Turkey & Italy Cruise with Celebrity Cruises
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 18 June 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
-
OCEANVIEW
$3,986
BALCONY
$5,055
SUITE
-
Save 4,288
From 3,986
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
View Trip
15 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
Exclusive Deal
INSIDE
$2,677
OCEANVIEW
$3,122
BALCONY
$3,469
SUITE
$8,518
From 2,677
View Trip
13 Day Roman Holiday To Toulon & Beyond with Regent Seven Seas
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 14 November 2025
Countries Visited: Italy, France, Spain, Corsica (+1 more), Sardinia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,468
SUITE
$15,824
Save 6,472
From 13,468
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 15 September 2025
Countries Visited: Italy, Sicily, Tunisia, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,909
From 18,909
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking Offer
INSIDE
$1,702
OCEANVIEW
$1,831
BALCONY
$2,098
SUITE
-
From 1,702
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 28 October 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive Deal
INSIDE
$774
OCEANVIEW
-
BALCONY
$1,061
SUITE
-
From 774
View Trip
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 July 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$2,179
OCEANVIEW
$2,278
BALCONY
$2,674
SUITE
$5,149
From 2,179
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 02 June 2025
Countries Visited: Italy, Croatia, Malta, Corsica (+1 more), Spain
Exclusive Deal
INSIDE
$2,627
OCEANVIEW
$2,974
BALCONY
$3,271
SUITE
$8,221
From 2,627
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 16 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$344
OCEANVIEW
$403
BALCONY
$492
SUITE
$829
From 344
View Trip
8 Day Spain And Adriatic with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 23 September 2024
Countries Visited: Italy, Croatia, Malta, Spain
Exclusive Deal
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,674
SUITE
$11,683
From 1,882
View Trip
Results: 61-90 of 130

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