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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 231 departures available from sixteen of the world's leading cruise lines.
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130 Cruises (231 Cruise Departures)
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,161
SUITE
$19,002
Save 6,959
From 17,161
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 July 2025
Countries Visited: Italy, Sicily, Monaco, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,981
OCEANVIEW
$3,575
BALCONY
$4,743
SUITE
$5,813
From 2,981
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 14 June 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,083
OCEANVIEW
$5,358
BALCONY
$5,814
SUITE
$7,348
From 4,083
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,727
OCEANVIEW
$4,452
BALCONY
$6,056
SUITE
$7,066
From 3,727
View Trip
22 Day Venice to Barcelona with Silversea
Cruise

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 26 July 2024
Countries Visited: Italy, Croatia, Montenegro, Albania (+5 more), Malta, Sicily, Sardinia, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,582
BALCONY
$23,265
SUITE
$36,333
From 21,582
View Trip
9 Day Springtime Rivieras with Oceania Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 May 2025
Countries Visited: Italy, Corsica, France, Spain
Cabin Upgrade Offer
INSIDE
$4,734
OCEANVIEW
$5,417
BALCONY
$6,338
SUITE
$7,021
From 4,734
View Trip
8 Day A Journey Of Limoncello Days And Catalonia Nights with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,613
SUITE
$6,826
From 5,613
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,047
OCEANVIEW
$5,051
BALCONY
$6,427
SUITE
$7,497
From 4,047
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Jul 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,940
SUITE
$7,247
From 5,940
View Trip
8 Day Italy, France, & Spain Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 10 August 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive Offer
INSIDE
$1,796
OCEANVIEW
$2,039
BALCONY
$2,545
SUITE
$5,497
Save 2,259
From 1,796
View Trip
15 Day Spain, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,776
OCEANVIEW
$3,073
BALCONY
$3,469
SUITE
$8,518
From 2,776
View Trip
22 Day Mediterranean And Greek Islands with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 23 September 2024
Countries Visited: Italy, Croatia, Malta, Spain (+3 more), Greece, Turkey, Sicily
Exclusive Deal
INSIDE
$4,659
OCEANVIEW
$5,600
BALCONY
-
SUITE
-
From 4,659
View Trip
8 Day A Journey From Rome To Tarragona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 September 2024
Countries Visited: Spain, Malta, Sicily, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,014
SUITE
$7,311
From 6,014
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,486
OCEANVIEW
$1,734
BALCONY
$1,932
SUITE
$4,258
From 1,486
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 June 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
Exclusive Deal
INSIDE
$2,776
OCEANVIEW
$3,073
BALCONY
$3,469
SUITE
$8,518
From 2,776
View Trip
10 Day Italy to France & Spain with Virgin Voyages
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 07 October 2025
Countries Visited: Italy, Sardinia, Corsica, France (+1 more), Spain
INSIDE
$2,775
OCEANVIEW
$2,874
BALCONY
$3,144
SUITE
$6,417
From 2,775
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jul 2024 to Oct 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$2,613
OCEANVIEW
$2,711
BALCONY
$3,315
SUITE
$8,142
Save 3,397
From 2,613
View Trip
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
21 Day Elegance In The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,773
SUITE
$27,437
Save 9,127
From 24,773
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 14 October 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Offer
INSIDE
$3,102
OCEANVIEW
$3,902
BALCONY
$4,939
SUITE
$11,265
Save 3,863
From 3,102
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 28 October 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,061
SUITE
-
From 1,061
View Trip
12 Day Greece, Turkey & Italy Cruise with Celebrity Cruises
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 18 June 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
-
OCEANVIEW
$3,985
BALCONY
$11,005
SUITE
-
Save 4,289
From 3,985
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$804
OCEANVIEW
$933
BALCONY
$1,111
SUITE
$1,992
From 804
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 05 August 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,725
OCEANVIEW
$3,288
BALCONY
$3,391
SUITE
$8,496
Save 3,477
From 2,725
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
View Trip
Results: 91-120 of 130

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