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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 224 departures available from sixteen of the world's leading cruise lines.
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126 Cruises (224 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+3 more), Viking Sky, Viking Star, Viking Vesta
Departures: Jun 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$6,925
SUITE
$10,390
Save 1,372
From 6,925
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,934
OCEANVIEW
-
BALCONY
$4,237
SUITE
$5,151
From 2,934
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Oct 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,171
From 4,450
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
Circle Club Voyage
INSIDE
-
OCEANVIEW
-
BALCONY
$4,219
SUITE
$5,512
From 4,219
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$5,715
SUITE
$6,490
From 5,715
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,829
BALCONY
$5,519
SUITE
$7,588
From 4,368
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
View Trip
11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
$4,418
OCEANVIEW
$5,557
BALCONY
$6,398
SUITE
$9,091
Save 2,032
From 4,418
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 May 2024
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
-
OCEANVIEW
$5,514
BALCONY
$7,521
SUITE
$11,981
From 5,514
View Trip
22 Day Western Mediterranean: Lisbon Overnight with Holland America
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+6 more), Tunisia, Sardinia, Spain, Morocco, Portugal, Gibraltar
Have It All Offer
INSIDE
$6,769
OCEANVIEW
$7,561
BALCONY
$8,997
SUITE
$12,066
From 6,769
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$5,210
OCEANVIEW
$5,899
BALCONY
$6,819
SUITE
$9,348
From 5,210
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,161
SUITE
$19,002
Save 6,959
From 17,161
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 August 2025
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
4 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Oasis of the Seas
Departures: Sep 2024 to Oct 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$1,323
OCEANVIEW
$1,474
BALCONY
$1,572
SUITE
$2,326
Save 653
From 1,134
View Trip
13 Day Mediterranean with MSC Cruises
Cruise

13 Days (12 Nights) Venice to Palma de Mallorca
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 17 November 2024
Countries Visited: Italy, Croatia, Montenegro, Spain (+2 more), Sardinia, France
Best Deal Offer
INSIDE
$1,942
OCEANVIEW
$2,328
BALCONY
-
SUITE
$4,051
From 1,942
View Trip
12 Day A Journey From Rome To Barcelona with Explora Journeys
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,093
SUITE
$9,875
From 8,093
View Trip
12 Day Cultures of the Mediterranean with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 29 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,568
Save 2,627
From 12,568
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$2,001
SUITE
$4,189
From 1,516
View Trip
8 Day Azure Summer with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,034
SUITE
$9,766
Save 5,826
From 9,034
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,111
SUITE
-
Save 2,069
From 8,111
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking Offer
INSIDE
$1,702
OCEANVIEW
$1,831
BALCONY
$2,098
SUITE
-
From 1,702
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 09 June 2025
Countries Visited: Italy, Corsica, Spain
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$3,964
SUITE
$8,518
From 3,172
View Trip
12 Day Italy, Greece & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Venice to Barcelona
Ship: Norwegian Escape
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), France, Spain
Exclusive Solo Offer
INSIDE
$2,276
OCEANVIEW
$2,581
BALCONY
$2,964
SUITE
$3,270
From 2,276
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,654
From 1,684
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,411
SUITE
$42,860
From 22,411
View Trip
Results: 1-30 of 126

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