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All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 552 cruises, small group tours and adventures to Panama travelling with the world's leading tour operators.
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6 Days
134 Days
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234 Trips (552 Trip Departures)
Featured17 Day Miami to LA via Panama Canal with Virgin Voyages
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departure: 21 March 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$5,508
OCEANVIEW
$6,054
BALCONY
$7,076
SUITE
$21,334
From 5,508
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Aug 2024 to Mar 2025
Trip Styles: Group, Short Break, Scenic
Countries Visited: Panama
Exclusive Savings
Save 50
From 2,312
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12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
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12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2025 to Jan 2025
Trip Styles: Group, Cruise
Countries Visited: Costa Rica, Panama
From 13,640
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12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Jun 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Savings
Save 44
From 1,837
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10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,311
SUITE
$10,746
Save 3,084
From 8,311
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14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
INSIDE
$5,330
OCEANVIEW
$6,394
BALCONY
$7,544
SUITE
$8,809
From 5,330
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,509
SUITE
$18,815
Save 6,636
From 13,509
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14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Oct 2024 to Nov 2025
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Exclusive Savings
Save 147
From 6,997
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8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$4,158
BALCONY
$5,049
SUITE
-
From 4,158
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8 Day Lima to Panama City with Silversea
Cruise

8 Days (7 Nights) Lima to Panama City
Cruise Line: Silversea
Ship: Silver Ray
Departure: 04 January 2025
Countries Visited: Peru, Ecuador, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$4,554
From 4,554
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11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,440
SUITE
$12,816
Save 3,605
From 10,440
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15 Day Treasures Of The Pacific Coast - Panama To Chile with Hurtigruten
Cruise

15 Days (14 Nights) Colon to Valparaiso
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 07 October 2024
Countries Visited: Panama, Ecuador, Peru, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
$6,549
BALCONY
-
SUITE
$9,145
Save 2,271
From 6,549
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9 Day Cartagena to Lima with Silversea
Cruise

9 Days (8 Nights) Cartagena to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 27 December 2024
Countries Visited: Colombia, Panama, Ecuador, Peru
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,207
From 9,207
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12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Exclusive DealEarlybird Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$19,939
SUITE
$25,126
Save 7,201
From 19,939
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10 Day Panama City to Fort Lauderdale with Silversea
Cruise

10 Days (9 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 11 January 2025
Countries Visited: Aruba, Colombia, Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$6,682
From 6,682
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17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departures: Jan 2026 to Apr 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$4,380
OCEANVIEW
$4,687
BALCONY
$5,845
SUITE
$8,062
From 4,380
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19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
Exclusive Deal
INSIDE
$2,330
OCEANVIEW
-
BALCONY
$3,053
SUITE
$3,884
From 2,330
View Trip
18 Day New York To San Francisco with Cunard
Cruise

18 Days (17 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Anne
Departure: 18 January 2025
Countries Visited: USA, Aruba, Panama, Guatemala (+1 more), Mexico
Exclusive Deal
INSIDE
$5,450
OCEANVIEW
$7,945
BALCONY
$8,717
SUITE
-
From 5,450
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
13 Day Fort Lauderdale to Lima with Silversea
Cruise

13 Days (12 Nights) Fort Lauderdale to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 20 January 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+1 more), Peru
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,880
From 11,880
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
Exclusive Solo Offer
INSIDE
$1,973
OCEANVIEW
$2,201
BALCONY
$3,379
SUITE
$3,533
From 1,973
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
INSIDE
$2,370
OCEANVIEW
$2,829
BALCONY
$3,977
SUITE
$4,282
From 2,370
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Viking Cruises
Ships: Viking Neptune, Viking Sky
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Colombia, Panama (+1 more), Costa Rica
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$19,795
Save 1,110
From 9,895
View Trip
19 Day Los Angeles to Fort Lauderdale with Silversea
Cruise

19 Days (18 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,058
BALCONY
$15,345
SUITE
$24,948
From 14,058
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ship: Norwegian Joy
Departure: 30 November 2024
Countries Visited: USA, Colombia, Panama, Guatemala (+1 more), Mexico
INSIDE
$2,943
OCEANVIEW
$3,249
BALCONY
$3,967
SUITE
$4,273
From 2,943
View Trip
10 Day Western Caribbean Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2024 to Feb 2025
Countries Visited: USA, Cayman Islands, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$1,719
OCEANVIEW
$1,543
BALCONY
$1,664
SUITE
$4,646
Save 1,261
From 1,541
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Neptune
Departure: 05 April 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$20,785
Save 1,110
From 10,885
View Trip
13 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

13 Days (12 Nights) Miami to Lima
Ship: Norwegian Jade
Departure: 27 February 2026
Countries Visited: USA, Colombia, Panama, Ecuador (+1 more), Peru
INSIDE
$3,763
OCEANVIEW
$3,947
BALCONY
$6,013
SUITE
$6,212
From 3,763
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2026
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$17,815
SUITE
$25,735
Save 1,180
From 17,815
View Trip
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